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THE EFFECT IN VIVO OF PERITONEAL EXUDATE CELLS OF IMMUNE AND NORMAL MICE ON THE INFECTIVITY OF THE THIRD STAGE LARVAE OF NEMATOSPIROIDES DUBIUS
Author(s) -
Chaicumpa V,
Jenkin CR,
Fischer H
Publication year - 1977
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1977.55
Subject(s) - peritoneal cavity , immune system , exudate , biology , infectivity , in vivo , larva , immunity , immunology , parasite hosting , microbiology and biotechnology , anatomy , virus , ecology , botany , world wide web , computer science
Summary Data presented show that in vivo peritoneal exudate cells of mice immune to infection with Nematospiroides dubius are capable of damaging the infective third stage larvae of this parasite. Experiments utilising chambers closed with membranes of different pore size and implanted in the peritoneal cavity indicated that damage requires intimate contact between the cells and larvae. Examination of the cells in contact with the larvae revealed that these cells were predominantly macrophages. The fact that peritoneal exudate cells of normal mice are unable to damage the third stage larvae even in the presence of serum from immune animals, although binding to the larvae, suggest that cells of immune mice have been “activated”.