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CHANGES IN ORNITHINE DECARBOXYLASE ACTIVITY AND CYCLIC ADENOSINE‐3′‐5′‐MONOPHOSPHATE CONCENTRATIONS DURING THE CELL CYCLE OF SYNCHRONIZED BHK CELLS
Author(s) -
Hibasami Hiroshige,
Tanaka Minoru,
Nagai Jun,
Ikeda Tadao
Publication year - 1977
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1977.34
Subject(s) - ornithine decarboxylase , chemistry , adenosine , microbiology and biotechnology , ornithine decarboxylase antizyme , biochemistry , enzyme , biology
Summary BHK cells were synchronized by excess thymidine treatment which rested in approximately 90% synchrony. The activity of ornithine decarboxylase (ODC), the rate‐limiting enzyme in polyamine biosynthesis, elevated in early S phase, decreased in G 2 + M and G 1 phase and then increased during late G 1 ∼ second round of early S phase. The concentration of cyclic adenosine‐3′‐5’monophosphate (cAMP) gradually decreased during SG 2 + M phase and then increased during late G 1 second round of early S phase. preceding that of ODC activity. The data Suggest that ODC activity might be regulated by cellular cAMP level.

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