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ERYTHROCYTE AUTOANTIBODIES INDUCED IN MICE IMMUNIZED WITH RAT ANTIGENS
Author(s) -
Keast D,
Calagero C
Publication year - 1977
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1977.31
Subject(s) - autoantibody , antigen , in vivo , antibody , immunology , in vitro , biology , chemistry , microbiology and biotechnology , biochemistry
Summary Antibody reacting against syngeneic mouse erythrocytes could not be elicited (by rat erythrocytes) in athymie nude mice. Rat antigen preparations from heart, muscle, testes, brain erythrocyte ghosts and foetal material failed to elicit detectable autoantibody reactivity against mouse erythrocytes, even though all these preparations (other than brain and foetal) induced a reduction in half life of syngeneic murine erythrocytes in vivo . We suggest that an unstable rat erythrocyte antigen is responsible for the induction of the autoimmune reactions, which in turn depend on T‐cells for their generation.