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PROSTAGLANDIN IN THE SALIVA OF THE CATTLE TICK BOOPHILUS MICROPLUS
Author(s) -
Dickinson RG,
O'Hagan JE,
Schotz Martina,
Binnington KC,
Hecarty MP
Publication year - 1976
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1976.48
Subject(s) - saliva , tick , prostaglandin , incubation , bradykinin , contraction (grammar) , anaphylaxis , chemistry , fractionation , biology , endocrinology , pharmacology , immunology , biochemistry , allergy , chromatography , receptor , virology
Summary Previous studies of saliva from engorged female cattle ticks revealed a component which induced contraction of some isolated smooth muscles. Fractionation and further characterisation have shown that this substance is of the “slow‐reacting” type, but that it is neither a bradykinin nor slow‐reacting substance of anaphylaxis. The substance is deactivated by incubation with 15‐hydroxyprostaglandin dehydrogenase and its pharmacological properties also support its classification as a prostaglandin. A second pharmacologically‐active component has now been found in the saliva but has not yet been characterised.