Premium
THE INFLUENCE OF ADRENERGIC NERVES ON THE RESPONSE OF BLOOD VESSELS IN THE RABBIT EAR TO 2‐PHENYLALANINE‐8‐LYSINE VASOPRESSIN (OCTAPRESSIN )
Author(s) -
Gerke DC,
Frewin DB,
Frost BR
Publication year - 1976
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1976.47
Subject(s) - tachyphylaxis , phentolamine , endocrinology , medicine , long term potentiation , vasopressin , adrenergic , physostigmine , rabbit (cipher) , blood vessel , chemistry , acetylcholine , receptor , stimulation , statistics , mathematics
Summary The blood vessels in the rabbit ear have been used to investigate the effects of octapressin on vascular smooth muscle. Continuous administration of this drug resulted in tachyphylaxis. Cocaine enhanced the response of the ear to octapressin; however, this potentiation was not evident when phentolamine was concurrently added to the perfusate. Denervation and reserpinisation of the ear also eliminated the potentiation of octapressin's response by cocaine. The results suggest that there is a small, indirect sympathomimetic component involved in octapressin's action on the vasculature.