Premium
THE EFFECTS OF 2‐PHENYLALANINE 8‐LYSINE VASOPRESSIN (OCTAPRESSIN) ON BLOOD VESSELS IN THE RAT TAIL
Author(s) -
Frost BR,
Gerke DC,
Frewin DB
Publication year - 1976
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1976.40
Subject(s) - tachyphylaxis , vasopressin , medicine , serotonin , endocrinology , stimulation , vascular smooth muscle , artery , blood vessel , chemistry , smooth muscle , biology , receptor
Summary Isolated perfused segments of the ventral rat tail artery have been used in this study to investigate the effects of octapressin on vascular smooth muscle and its interaction with other vasoconstrictor agents. It was found that repeated octapressin administration was associated with tachyphylaxis and that the onset and rate of development of this phenomenon could he modified by cocaine. The constrictor action of catecholamines, electrical stimulation and serotonin on the rat tail artery as potentiated by octapressin. Mechanisms which may be involved in octapressin tachyphylaxis are discussed.