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INHIBITION OF INTESTINAL UPTAKE OF AMINO ACIDS BY UNCONJUGATED BILE SALT
Author(s) -
Burke Valerie,
Gracey Michael,
Thomas Jennifer,
Malajczuk Anne
Publication year - 1976
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1976.39
Subject(s) - amino acid , glycine , small intestine , biochemistry , chemistry , proline , leucine , lysine , in vivo , deoxycholic acid , sodium , tyrosine , bile acid , medicine , biology , microbiology and biotechnology , organic chemistry
Summary The unconjugated bile salt, sodium deoxycholate, at a concentration of 0·5 mM was shown to inhibit the intestinal uptake of the amino acids L‐glycine, L‐leucine, L‐proline, L‐lysine and L‐tyrosine in rats in vitro . This effect was acutely reversible except for tile basic amino arid L‐lysine and is therefore not simply due to tissue damage. These results, and the recent finding that sodium deoxycholate inhibits intestinal absorption of amino acids in vivo , suggest that impaired intestinal amino acid transport may contribute to hypo‐proteinaemia in patients with bacterial overgrowth in the upper small intestine in whom deoxycholate is present in the small intestinal lumen in excessive concentrations.