Premium
RESISTANCE OF MICE TO KREBS ASCITES TUMOUR, SARCOMA S180 AND PC6 PLASMACYTOMA AFTER IMMUNISATION WITH SALMONELLA ENTERITIDIS 11RX
Author(s) -
Tindle RW,
Neoh SH,
Ashley MP,
Hardy D,
Kotlarski Ieva
Publication year - 1976
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1976.15
Subject(s) - salmonella enteritidis , salmonella , plasmacytoma , ascites , antigen , sarcoma , in vivo , neoplasm , medicine , biology , immunology , microbiology and biotechnology , virology , pathology , multiple myeloma , bacteria , genetics
Summary Resistance to Krebs ascites tumour, sarcoma S180 (ascitic form) and PC6 plasmacytoma can be induced with prior immunisation with live Salmonella enteritidis 11RX. One thousand to ten thousand more tumour cells are needed to give an LD 50 after immunisation. Resistance to PC6 could be recalled 137 days after intravenous immunisation with 11RX protein antigen intraperitoneally as measured by prolonged survival or monitoring the death of 5[ 131 I]‐iodo‐2′‐deoxyuridine labelled tumour cells in vivo . The range of tumours to which resistance can be produced by 11RX immunisation suggests that the mechanism of resistance does not involve antigens common to the tumours and Salmonella enteritidis 11RX.