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THE SURFACE MORPHOLOGY AND THE CELL CYCLE OF MASTOCYTOMA TARGET CELLS: NO APPARENT EFFECT ON CELL‐MEDIATED KILLING
Author(s) -
Ching LM,
Gavin JB,
Marbrook J,
Skinner M
Publication year - 1976
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1976.14
Subject(s) - mastocytoma , morphology (biology) , lysis , cell , cytotoxic t cell , cell cycle , chemistry , biophysics , microbiology and biotechnology , biology , in vitro , biochemistry , genetics
Summary Mastocytoma cells (P‐185) have been separated by velocity sedimentation into fractions which were highly enriched for cells at discrete stages of the cell cycle. By scanning electron microscopy it was shown that the surface morphology of the majority of cells in each fraction was characteristic of that fraction. No difference could be detected between isolated fractions and unfractionated cells in their ability to be lysed by cytotoxic lymphocytes.