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DEPRESSION OF JEJUNAL DIPEPTIDE TRANSPORT BY PYRIDOXINE DEFICIENCY IN THE RAT
Author(s) -
Gupta Vatsala J,
Edwards KDG,
Asatoor AM
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.9
Subject(s) - dipeptide , pyridoxine , pyridoxine deficiency , chemistry , amino acid , in vivo , histidine , efflux , medicine , biochemistry , biology , microbiology and biotechnology
Summary Three dipeptides (L‐alanyl‐L‐alanine, β‐alanyl‐L‐histidine and L‐prolylglycine), representative of distinctly different transport groups, and a dicarboxylic acid dipeptide (L‐glutamyl‐L‐glutamic acid) showed a quantitatively equivalent decrease of absorption (mean difference, 12% disappearance 15 min −1 5 cm −1 ) from jejunal loops in vivo in pyridoxine deficient rats, compared with pyridoxine‐repleted controls. Analysis of results for seven dipeptides, including three studied previously, indicated that pyridoxine deficiency caused a general or non‐specific reduction in dipeptide transport, similar for all dipeptides. Decrease in dipeptide transport in vitamin deficiency ran parallel to, but was significantly less than, the decrease in amino acid transport, suggesting in theory involvement of pyridoxine in a common cellular efflux mechanism or, less likely, in the energetics of active transport.