Premium
AN ISOTOPIC STUDY OF OXALATE EXCRETION IN SHEEP
Author(s) -
McIntosh GH,
Belling GB
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.53
Subject(s) - oxalate , excretion , clearance , chemistry , calcium oxalate , inulin , endocrinology , kidney , medicine , urinary system , calcium , urine , sodium oxalate , biochemistry , biology , urology , inorganic chemistry
Summary Intravenously injected 14 C labelled oxalate was rapidly removed from the blood stream via the kidney in 2 sheep, 75% being cleared within 8 h. Mean daily urinary oxalate excretions over 5 days were 21·2 and 27·5 mg and the derived plasma oxalate concentrations were 52·6 and 74·4 μg/100 ml, respectively. Oxalate was both filtered and secreted by the renal tubule with oxalate/inulin ratios varying from 1·11 to 1·57 in 6 normal sheep. A large increase in calcium excretion induced by calcium borogluconate infusion over 5 days was accompanied by a small but consistent increase in urinary oxalate excretion relative to calcium. Oxalate in blood was to be found mainly in the plasma, there being a small (8%) proportion within erythrocytes. This is lower than that reported for man, and yet in its excretion of oxalate via the kidney the sheep appears to closely resemble man and dog.