Premium
FACILITATION OF THE GROWTH OF AN ALLOGENEIC TUMOUR BY SUPPRESSOR CELLS IN NEWBORN RATS
Author(s) -
Van Der Gaag Ruth,
McCullagh Peter
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.47
Subject(s) - immune system , adoptive cell transfer , suppressor , immunology , immunity , biology , programmed cell death , medicine , andrology , t cell , cancer , apoptosis , biochemistry
Summary The intravenous injection of as few as 15 Walker tumour cells into newborn rats consistently resulted in the development of pulmonary metastases and the death of the recipient within 2 weeks. Neither the outcome of tumour cell injection nor the interval until death could be modified by transferring 2 × 10 7 lymphocytes from tumour‐immune adult rats to the neonatal hosts. In contrast with this failure to transfer adoptive anti‐tumour immune responses to intact recipients, the administration of 350 rad irradiation before transfer of 10° immune lymphocytes constantly afforded protection against inoculated tumour cells. The simultaneous transfer of neonatal thymus cells with immune lymphocytes interfered with the establishment of an adoptive response in the irradiated newborn. Initiation of a graft‐versus‐host response in F 1 hybrid neonates by injecting parental strain lymphocytes conferred resistance to tumour growth on the recipient, the magnitude of this effect increasing with the strength of the graft‐versus‐host reaction.