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CELL POPULATIONS IN A RENAL LESION PRODUCED BY LOCAL INJECTION OF XENOGENEIC SPLEEN CELLS IN CYCLOPHOSPHAMIDE‐TREATED RATS
Author(s) -
Conway MS,
Davies DJ
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.38
Subject(s) - spleen , lesion , cyclophosphamide , kidney , pathology , cell , lymphocyte , staining , lymphatic system , cortex (anatomy) , biology , chemistry , immunology , medicine , endocrinology , chemotherapy , biochemistry , neuroscience
Summary The frequency and distribution of donor and host lymphoid tells in different stages of a lesion produced by injecting mouse spleen cells beneath the renal capsules of rats treated 24 h previously with cyclophosphamide have been studied by imniunofluorescent staining with species‐specific anti‐lymphocyte sera. Donor cells were predominant in the early stages of the reaction and penetrated the outer part of the renal cortex, but by day 7 when the lesion reached its maximum extent most of the infiltrating cells were of host origin. Donor cells never extended deeply into the kidney and they were not uniformly intermingled with the main mass of host cells hut their presence seemed to be necessary for the maintenance of the reaction, since it began to decline when donor cells were no longer detectable in the injected kidney.