Premium
CORTISONE‐RESISTANT EFFECTOR T CELLS IN ACUTE LYMPHOCYTIC CHORIOMENINGITIS AND LISTERIA MONOCYTOGENES INFECTION OF MICE
Author(s) -
Zinkernagel RM,
Doherty PC
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.32
Subject(s) - lymphocytic choriomeningitis , listeria monocytogenes , cortisone , effector , immune system , immunology , microbiology and biotechnology , listeria infection , biology , cortisone acetate , virology , medicine , listeria , bacteria , endocrinology , cd8 , genetics
Summary Sensitized T cells in both lymphocytic choriomeningitis (LCM) and listeriosis are apparently unaffected by treatment of mice with cortisone acetate. Cortisone‐resistant immune T cells readily transfer acute, fatal LCM or protection against L. monocytogenes infection. Treatment of recipient mice with cortisone, however, impairs T cell‐dependent effector mechanisms (i.e. macrophages) in listeriosis, but has no effect on induction of LCM. Acute LCM may thus represent a T cell‐mediated pathological process which does not require participation of macrophages.