CORTISONE‐RESISTANT EFFECTOR T CELLS IN ACUTE LYMPHOCYTIC CHORIOMENINGITIS AND  LISTERIA MONOCYTOGENES  INFECTION OF MICE | Zendy

Zinkernagel RM | Zendy; Doherty PC | Zendy

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CORTISONE‐RESISTANT EFFECTOR T CELLS IN ACUTE LYMPHOCYTIC CHORIOMENINGITIS AND LISTERIA MONOCYTOGENES INFECTION OF MICE

Author(s) -

Zinkernagel RM,

Doherty PC

Publication year - 1975

Publication title -

australian journal of experimental biology and medical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0004-945X

DOI - 10.1038/icb.1975.32

Subject(s) - lymphocytic choriomeningitis , listeria monocytogenes , cortisone , effector , immune system , immunology , microbiology and biotechnology , listeria infection , biology , cortisone acetate , virology , medicine , listeria , bacteria , endocrinology , cd8 , genetics

Summary Sensitized T cells in both lymphocytic choriomeningitis (LCM) and listeriosis are apparently unaffected by treatment of mice with cortisone acetate. Cortisone‐resistant immune T cells readily transfer acute, fatal LCM or protection against L. monocytogenes infection. Treatment of recipient mice with cortisone, however, impairs T cell‐dependent effector mechanisms (i.e. macrophages) in listeriosis, but has no effect on induction of LCM. Acute LCM may thus represent a T cell‐mediated pathological process which does not require participation of macrophages.

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