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THE EFFECTS OF A NEW XANTHINE DERIVATIVE, 3,7‐DIMETHYL‐1(5‐OXOHEXYL)‐XANTHIN (PENTOXIFYLLINE) ON THE GENERAL AND CARDIAC HAEMODYNAMICS OF THE INTACT ANIMAL
Author(s) -
Maxwell GM
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.29
Subject(s) - coronary sinus , pentoxifylline , medicine , hemodynamics , heart rate , cardiology , cardiac output , xanthine , blood pressure , chemistry , biochemistry , enzyme
Summary A study has been made of the effects of xanthine derivative (pentoxifylline) upon the general and cardiac‐ haemodynamics of intact anaesthetised dogs. The drug increased heart‐rate, respiration rate, cardiac output and systemic pressure. It reduced mean pulmonary arterial pressure. Coronary flow was increased for only a few minutes, but coronary sinus O 2 content increased throughout the study. Lactate and pyruvate values increased in both artery and coronary sinus, as did the cardiac extraction of these substances. Cardiac extraction of non‐esterified fatty acid increased.