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INHIBITION BY SERUM OF AUTOIMMUNE ASPERMATOGENIC ORCHITIS
Author(s) -
Bernard CC,
Toullet Francine,
Lamoureux G
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.26
Subject(s) - orchitis , guinea pig , antigen , antibody , immunology , humoral immunity , immunity , biology , medicine , endocrinology , immune system , pathology
Summary Inhibition by serum of experimental autoimmune orchitis (EAO) was studied in guinea‐pigs. It was found that the capacity of an autoantigen, antigen P, purified from guinea‐pigs' spermatozoa, to produce lesions of EAO could be inhibited by mixing antigen P with a small amount of normal human serum before injection into guinea‐pigs. In protected animals, cell‐mediated immunity and humoral antibodies to antigen P were also significantly suppressed.