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SOME EVIDENCE FOR THE MATURITY OF PERIPHERAL ADRENERGIC NERVES IN NEW‐BORN GUINEA‐PIGS
Author(s) -
O'Donnell Stella R,
Saar Nili
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.22
Subject(s) - guinea pig , adrenergic , peripheral , sympathectomy , endocrinology , medicine , biology , ontogeny , receptor
Summary The fluorescence histochemical technique of Falck and Hillarp revealed a similar distribution and density of peripheral adrenergic nerves in new‐born and adult guinea‐pigs. The accumulation of tritiated noradrenaline by tracheae from new‐born guinea‐pigs, assumed to be uptake into adrenergic nerves, was not less than the accumulation by tracheae from adult animals. There was equal potentiation by cocaine (1 × 10 −5 M) of responses to noradrenaline on tracheal chain preparations taken from new‐born and adult guinea‐pigs. The evidence supports the hypothesis that the guinea‐pig has a functional, well differentiated peripheral adrenergic nervous system at birth. This would account for the apparent inability to produce a long‐lasting sympathectomy by administration of 6‐hydroxydopamnie to new‐born guinea‐pigs.