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THE ORIGIN OF THE IMMUNOGLOBULINS IN INTESTINAL LYMPH OF SHEEP
Author(s) -
Quin JW,
Husband AJ,
Lascelles AK
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.21
Subject(s) - lymph , lamina propria , antibody , pathology , lymphatic system , iodine , plasma cell , mesenteric lymph nodes , chemistry , biology , medicine , immunology , spleen , epithelium , organic chemistry
Summary Various immunoglobulins were labelled with radioactive iodine and their distribution between intestinal lymph and plasma followed in order to determine the origin of the immunoglobulins found in intestinal lymph. By comparing specific activities in plasma and lymph, it was computed that 25% of the IgG 1 and IgG 2 and 90% of the IgA in intestinal lymph were locally synthesised. The results suggest that virtually all of the IgA and a proportion of the IgG 1 computed to be synthesised locally were derived from plasma cells of corresponding specificity in the lamina propria of the intestine.