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EFFECTS OF THYMUS‐INDEPENDENT (B) CELLS AND THE H‐2 GENE COMPLEX ON ANTIVIRAL FUNCTION OF IMMUNE THYMUS‐DERIVED (T) CELLS
Author(s) -
Blanden Robert V,
Bowern Narelle A,
Pang Tikky E,
Gardner Ian D,
Parish Christopher R
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.19
Subject(s) - ectromelia virus , biology , ectromelia , immune system , virus , in vitro , virology , antibody , antigen , spleen , in vivo , b 1 cell , antigen presenting cell , t cell , microbiology and biotechnology , immunology , gene , biochemistry , vaccinia , recombinant dna
Summary Antiviral activity in vivo exerted by ectromelia virus‐immune spleen cells transferred to ectromelia‐infected recipients and cytotoxicity against virus‐infected target cells in vitro were both properties of non‐immunoglobulin (Ig)‐bearing cells (which included T cells). Ig‐bearing cells, including thymus‐independent (B) cells and antibody‐secreting cells, were much less active in vivo when injected alone and tended to block rather than amplify the effect triggered by T cells. Ig‐bearing cells were also slightly active in vitro , possibly because some T cells have detectable Ig. Antiviral effects in cell transfer experiments were seen only when immune cell donors and infected recipients shared the same H‐2 gene complex. These results are consistent with the hypothesis that the T cell response to ectromelia infection is directed against specific virus‐induced change(s) in antigen(s), specified by gene(s) in the H‐2 complex, which appear in virus‐infected cells.