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ANTIBACTERIAL MECHANISMS IN THE INTESTINE
Author(s) -
Knop Jürgen,
Rowley Derrick
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.15
Subject(s) - antibody , sensitization , bacteria , small intestine , microbiology and biotechnology , large intestine , chemistry , biology , immunology , biochemistry , genetics
Summary The elimination of 32 ‐P‐labelled V. cholerae 569B from the gastrtointestinal tract of infant mice (6‐day‐old) and the role of passively administered antibacterial antibody in this process have been studied. Whereas infant mice removed the oral inoculum to some degree by the same mechanisms found in adult mice, antibody treatment of the bacteria increased the efficiency of these considerably. Antibody sensitization led to a more rapid mechanical removal of the organisms from the small intestine and the bacteria remaining in the intestine were killed more efficiently.