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ANTIBACTERIAL MECHANISMS IN THE INTESTINE
Author(s) -
Knop Jürgen,
Rowley Derrick
Publication year - 1975
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1975.14
Subject(s) - small intestine , microbiology and biotechnology , gastrointestinal tract , large intestine , bacteria , biology , peristalsis , biochemistry , genetics
Summary The elimination of 32 P‐labelled V. cholerae organisms from the gastrointestinal tract of adult mice has been followed. Orally inoculated V. cholerae organisms are rapidly reduced in viable numbers. The parameters involved in the elimination of the viable bacteria are killing by gastric acid, mechanical removal by peristalsis and killing in the small intestine. Inhibition of one or more of these parameters by different treatments delays or prevents the elimination of the organisms. Results obtained in starved animals suggest that secretory processes in the small intestine contribute to the killing of the organisms.