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RECALL OF TUMOUR RESISTANCE IN LONG‐TERM SALMONELLA ENTERITIDIS 11RX IMMUNISED MICE
Author(s) -
Ashley MP,
Kotlarski Ieva,
Hardy D
Publication year - 1974
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1974.86
Subject(s) - salmonella enteritidis , in vivo , salmonella , peritoneal cavity , antigen , microbiology and biotechnology , medicine , immunology , biology , bacteria , surgery , genetics
Summary Resistance to Ehrlich ascites tumour growth in the peritoneal cavity of mice has been induced by prior immunisation with live Salmonella enteritidis 11RX. A greater and longer lasting anti‐tumour effect was elicited after immunisation by the intraperitoneal (i.p.) route than by the intravenous (i.v.) route. Resistance to tumour could be recalled after either i.p. or i.v. immunisation by i.p. injection of various 11RX antigen preparations, including a preparation which was not protective in normal mice. Resistance was determined by following survival of mice after challenge with tumour cells and by monitoring the death of 131 I‐iododeoxyuridine‐labelled tumour cells in vivo . Recall of tumour resistance was attributed to the rapid induction of an in vivo tumour killing mechanism.