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THE ORIGIN OF ANTIBODY IN INTESTINAL SECRETION OF SHEEP
Author(s) -
Husband AJ,
Lascelles AK
Publication year - 1974
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1974.78
Subject(s) - secretion , brucella abortus , antibody , antigen , ferritin , biology , stimulation , immunology , medicine , antibody response , endocrinology , brucellosis
Summary Thiry and double re‐entrant jejunal loops were prepared in adult sheep and young lambs to study antibody responses following local and systemic administration of soluble and particulate antigens. Systemic administration of both living Brucella abortus and ferritin elicited an IgG response in serum and intestinal secretion. Repeated local infusions of living and killed Br. abortus into isolated intestinal loops failed to elicit a significant response. However, local infusions of egg albumin or ferritin resulted in the appearance in intestinal secretion of substantial amounts of antibody most of which was associated with IgA. The results obtained using lambs demonstrated that local antibody production associated with IgA occurred after antigenic stimulation of intestinal loops in animals as young as 3 weeks of age.