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IMMEDIATE HYPERSENSITIVITY RESPONSES IN THE MARSUPIAL SETONIX BRACHYURUS (THE QUOKKA). CHARACTERIZATION OF THE HOMOCYTOTROPIC ANTIBODY
Author(s) -
Lynch NR,
Turner KJ
Publication year - 1974
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1974.75
Subject(s) - biology , marsupial , antibody , hemagglutination , antiserum , sephadex , extant taxon , immunoglobulin e , zoology , immunology , evolutionary biology , biochemistry , enzyme
Summary The biological properties of the homocytotropic antibody (HCA) of the marsupial Setonix brachyurus (the quokka) were closely comparable to those of eutherian (placental species) IgE. However, the quokka HCA was indistinguishable from the IgG 1 class. Agar gel electrophoresis, Sephadex G‐200 chromatography and sequential elution from DEAE‐cellulose and CM‐cellulose did not separate the passive cutaneous anaphylactic (PCA) and IgG 1 passive haemagglutination (HA) activities in quokka antisera. No antigenic differences between the IgG 1 HA antibody and the HCA were detected. In addition to quokka IgG 1 , tissue‐fixing IgG has been demonstrated in eutherian and avian species and thus it is suggested that the extant IgG and IgE classes evolved from a primitive cytotropic γ chain.