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DIFFERENCES IN GENETIC SPECIFICITY ARE OBSERVED WHEN SPLEEN AND LYMPH NODE LEUCOCYTES ARE USED AS THE RESPONSIVE CELL POPULATION IN MIXED LEUCOCYTE CULTURES
Author(s) -
Lafferty KJ,
Ryan Madeleine A
Publication year - 1974
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1974.57
Subject(s) - spleen , lymph node , population , stimulation , biology , immunology , cell , microbiology and biotechnology , lymph node stromal cell , andrology , medicine , genetics , endocrinology , environmental health
Summary In mixed leucocyte culture, CBA lymph node cells respond to stimulation by irradiated (CBA x C57Bl) F 1 spleen cells, but (CBA x C57Bl) F 1 lymph node cells are not stimulated by irradiated CBA spleen cells. However, when spleen cells are the responsive cell population. (CBA x C57Bl) F 1 cells respond to stimulation by irradiated CBA spleen cells and CBA spleen cells respond to stimulation by irradiated (CBA x C57Bl) F 1 spleen cells.