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CLASS SPECIFICITY OF INTRACELLULAR AND SURFACE IMMUNOGLOBULIN OF CELLS IN POPLITEAL AND INTESTINAL LYMPH FROM SHEEP
Author(s) -
Beh KJ,
Lascelles AK
Publication year - 1974
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1974.49
Subject(s) - lymph , lymph node , antibody , surface immunoglobulin , immunology , immune system , lymph node stromal cell , lamina propria , immunoglobulin g , immunoglobulin a , lymphatic system , biology , immunoglobulin m , pathology , medicine , b cell , epithelium
Summary The proportion and class specificity of immunoglobulin‐containing cells in intestinal lymph of sheep have been compared with those in lymph from a popliteal lymph node undergoing an immune response. In addition, the proportion of cells with immunoglobulin determinants on their surface in lymph from both sources was determined. Following antigenic stimulation, IgM‐ and subsequently IgG 1 ‐specific cells appeared in the popliteal lymph; only small numbers of IgG 2 ‐ and IgA‐specific cells were seen. In contrast, immunoglobulin‐containing cells in intestinal lymph were almost exclusively IgA‐specific, and it was concluded that most of these cells originated from the lamina propria or Peyer's patches. The proportion of cells with immunoglobulin determinants on their surface in intestinal and popliteal lymph was around 28% and the immunoglobulin exposed on the surface was exclusively IgM.