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CELL CHANGES IN DUCK LYMPH FOLLOWING LOCAL CHALLENGE WITH ALLOGENEIC AND XENOGENEIC CELLS
Author(s) -
Bell RG
Publication year - 1974
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1974.44
Subject(s) - lymph , lymph node stromal cell , lymphocyte , biology , cell , population , buccal administration , pathology , immunology , submucosa , lymph node , medicine , genetics , bioinformatics , environmental health
Summary The injection of foreign cells into the buccal submucosa of the duck was shown to produce a characteristic pattern of changes in the draining cervical lymph cell population. These changes in the lymph‐borne cell population were monitored by the continuous collection of lymph from individual birds for a period of 5‐7 days after stimulation. During this period a 2‐7‐fold increase in mature lymphocyte output and a 5‐20‐fold increase in “blast” cell output occurred. The appearance of “blast” cells was the most consistent and characteristic parameter of a host response to the injected cells. The pattern of appearance of cell types other than the mature lymphocyte and “blast” cell was not altered during the period of lymph collection and responses were therefore specific for these two cell types. On the basis of histological studies, it was suggested that responses were predominantly mediated by host blood‐borne cells migrating into the injected site.