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FAILURE TO INDUCE AUTOIMMUNITY IN MICE WITH ENDOTOXIN
Author(s) -
Cox KO,
Keast D
Publication year - 1974
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1974.40
Subject(s) - clearance , in vivo , autoimmunity , immunology , immunity , medicine , chemistry , immune system , biology , microbiology and biotechnology , urology
Summary Prolonged immunisation of mice with endotoxin‐coated syngeneic erythrocytes provoked strong immunity against endotoxin. Endotoxin‐coated, 51 Cr‐labelled syngeneic erythrocytes were cleared faster in immunised mice compared with unimmunised mice. The clearance of allogeneic erythrocytes was unchanged. There was no autoimmune response against syngeneic erythrocytes as measured by direct Coombs’ tests and in vivo survival studies of 51 Cr‐labelled erythrocytes.