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LONG TERM LIVER RADIATION DAMAGE IN THE RAT FOLLOWING INTERNAL AND EXTERNAL IRRADIATION
Author(s) -
Waller AR,
Wordsworth OJ
Publication year - 1974
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1974.36
Subject(s) - liver damage , alanine aminotransferase , irradiation , medicine , histology , endocrinology , chemistry , nuclear medicine , pathology , nuclear physics , physics
Summary Liver radiation damage has been assessed and compared in the rat following two different liver irradiation regimes. (i) One group of rats received liver radiation doses ranging from 4,250 rads to 8,500 rads delivered externally in fractionated doses over 11 days by a 240 kV X‐ray machine. Liver damage was assessed by determining serum levels of alanine aminotransferase, aspartate aminotransferase and total haemolytic complement. (ii) A second group of rats received a liver radiation dose of 8,500 rads delivered internally via intravenously injected radioactive colloidal gold–198, and similar serum parameters were studied. Liver histology was also carried out on both groups of rats. Both treatments result in abnormal serum levels of enzymes and complement, and a comparison of results for both irradiation regimes indicates that, while there are slight differences in early response, particularly in serum complement levels, nevertheless similar long term liver damage results.