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STUDIES ON THE MECHANISM OF PROLONGATION OF PSEUDOPREGNANCY FOLLOWING SECTION OF UTERO‐OVARIAN VASCULAR CONNECTIONS IN THE RAT
Author(s) -
O'Shea JD,
Lee CS
Publication year - 1974
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1974.24
Subject(s) - uterine artery , uterus , medicine , luteolysis , blood flow , ovarian artery , in utero , uterine horns , ovary , spiral artery , endocrinology , anatomy , corpus luteum , biology , pregnancy , fetus , gestation , genetics , placenta
Summary Prolongation of pseudopregnancy in Hooded Wistar rats after unilateral hysterectomy accompanied by contralateral ovariectomy was not significantly different from that after section of the anterior uterine blood vessels. The effects of the former procedure could, therefore, be due entirely to interruption of these vessels. The effects of section of the utero‐ovarian, anterior uterine and uterine arteries, and of the anterior uterine vein, were compared. Only section of the anterior uterine artery significantly prolonged pseudopregnancy. The direction of blood flow along the anterior uterine artery was observed directly in anaesthetised rats after intra‐aortic injection of India ink. Flow was towards the uterus in 13 of 15 pseudopregnant rats on the 6th, 8th or 10th day of dioestrus. These data are discussed in relation to recent theories on local uterine luteolysis, and it is suggested that the effects of section of the anterior uterine artery may be due to a disturbance of ovarian circulation.