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GENERAL AND CORONARY HAEMODYNAMIC EFFECTS OF TWEEN 20
Author(s) -
Burnell RH,
Maxwell GM
Publication year - 1974
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1974.12
Subject(s) - nefa , coronary sinus , cardiac output , medicine , cardiology , hemodynamics , histamine , blood flow , heart rate , shock (circulatory) , blood pressure , anesthesia , chemistry , insulin
Summary Cardiac output, vascular pressures, coronary sinus flow, cardiac O 2 usage and efficiency, together with blood glucose and non‐esterified fatty acid (NEFA) values, were measured before and after the infusion of Tween 20 (polyoxyethylene sorbitan monolaurate) in intact anaesthetised dogs. This substance, which releases histamine, gave the following responses: an initial increase in cardiac output, coronary sinus flow and heart rate, with maintenance of systemic pressure; 3‐4 minutes later, cardiac output, vascular pressures and coronary flow decreased greatly, with a continuance of the tachycardia. Cardiac work decreased, as did cardiac efficiency; blood glucose levels did not change, but NEFA values and cardiac NEFA extraction increased. The biphasic response described is entirely compatible with histamine release, the later response being almost indistinguishable from that found in endotoxin or haemorrhagic shock.