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THE EFFECT OF ASPIRIN ON THE PULMONARY EXTRACTION OF PGF 2α , AND CARDIOVASCULAR RESPONSE TO PGF 2α
Author(s) -
Jackson HR,
Hall RC,
Hodge RL,
Gibson E,
Katic F,
Stevens M
Publication year - 1973
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1973.79
Subject(s) - aspirin , prostaglandin , medicine , prostaglandin e , anesthesia , cardiac output , cardiology , central venous pressure , prostaglandin e2 , blood pressure , heart rate
Summary Aspirin significantly inhibited the pulmonary extraction of prostaglandin F 2α . This effect of aspirin on the pulmonary circulation was associated with a significant change in the cardiovascular response to intravenous infusions of prostaglandin F 2α but no change in the response to arterial infusions. Before aspirin intravenous infusions of prostaglandin F 2α caused a significant fall in central venous pressure and a rise in cardiac output, while after aspirin prostaglandin F. 2α caused a rise in central venous pressure and a fall in cardiac output.