THE EFFECT OF ASPIRIN ON THE PULMONARY EXTRACTION OF PGF 2α , AND CARDIOVASCULAR RESPONSE TO PGF 2α | Zendy

Jackson HR | Zendy; Hall RC | Zendy; Hodge RL | Zendy; Gibson E | Zendy; Katic F | Zendy; Stevens M | Zendy

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THE EFFECT OF ASPIRIN ON THE PULMONARY EXTRACTION OF PGF 2α , AND CARDIOVASCULAR RESPONSE TO PGF 2α

Author(s) -

Jackson HR,

Hall RC,

Hodge RL,

Gibson E,

Katic F,

Stevens M

Publication year - 1973

Publication title -

australian journal of experimental biology and medical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0004-945X

DOI - 10.1038/icb.1973.79

Subject(s) - aspirin , prostaglandin , medicine , prostaglandin e , anesthesia , cardiac output , cardiology , central venous pressure , prostaglandin e2 , blood pressure , heart rate

Summary Aspirin significantly inhibited the pulmonary extraction of prostaglandin F 2α . This effect of aspirin on the pulmonary circulation was associated with a significant change in the cardiovascular response to intravenous infusions of prostaglandin F 2α but no change in the response to arterial infusions. Before aspirin intravenous infusions of prostaglandin F 2α caused a significant fall in central venous pressure and a rise in cardiac output, while after aspirin prostaglandin F. 2α caused a rise in central venous pressure and a fall in cardiac output.

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