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TUMOUR RESISTANCE OF MICE INFECTED WITH SALMONELLA ENTERITIDIS 11RX
Author(s) -
Ashley MP,
Hardy D
Publication year - 1973
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1973.76
Subject(s) - salmonella enteritidis , cytolysis , salmonella , in vivo , microbiology and biotechnology , spleen , peritoneal cavity , in vitro , ascites , biology , immunology , bacteria , medicine , cytotoxicity , biochemistry , genetics , anatomy
Summary The resistance to Ehrlich ascites tumour transplants in mice immunized with live Salmonella enteritidis 11RX was investigated. In mice still carrying the bacterial infection, the resistance appeared to be attributable to an increase in both the number and the anti‐tumour activity of the peritoneal cells. This activity was demonstrated in vivo run by the rapid removal of tumour cells from the peritoneal cavity and in vitro by the cytolysis of tumour cells. The spleen cells of resistant mice did not possess these properties.