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MODIFICATION OF THE RESPONSIVENESS OF F 1 HYBRID RATS TO LYMPHOCYTES FROM PARENTAL STRAIN RATS
Author(s) -
McCullagh Peter
Publication year - 1973
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1973.72
Subject(s) - strain (injury) , biology , lymphocyte , hybrid , phenotype , mitomycin c , immunology , genetics , gene , anatomy , botany
Summary An experimental protocol to modify the susceptibility of F 1 hybrid rats to graft‐versus‐host disease produced by parental strain lymphocytes has been described. This procedure entails preliminary exposure of the F 1 hybrids to parental strain lymphocytes which have been treated with mitomycin‐C The Susceptibility of F 1 hybrids treated in this manner to parental strain lymphocyte varies with the interval which has elapsed before the injection of normal parental strain lymphocytes. It appears that, in order to afford protection, the cells of the preliminary inoculum are required to engage the lymphoid cells of the host in an allogeneic interaction and that F 1 hybrid unresponsiveness on re‐exposure to parental strain cells reflects unresponsiveness of host lymphocytes. Concomitant modification of the susceptibility of F 1 hybrids to lymphocytes from donors of the Other parental strain was observed alter preliminary exposure to cells of one parental strain.