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THE HISTOLOGICAL CHANGES IN IMMUNOLOGICALLY TOLERANT LYMPHOID TISSUE
Author(s) -
Awaya Kazuhiko,
McCullagh Peter
Publication year - 1973
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1973.71
Subject(s) - lymph node , lymphatic system , medullary cavity , biology , lymph , pathology , immunology , anatomy , medicine
Summary The histological features of the regional lymph node draining a skin homograft have been examined in normal and tolerant recipients. The response of this node was morphologically identical in normal and specifically tolerant hosts, the most important feature being the appearance of medullary cords packed with intensely pyroninophilic cells. Furthermore, a similar response was observed in the regional lymph nodes of (DA × Lewis)F 1 hybrids bearing DA skin grafts of which they were “genetically tolerant”. It was concluded that the failure of graft rejection in tolerant rats could not be attributed to an absence of reactivity to the grafts on the part of the lymphoid tissue of the host.