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CONCOMITANT IMMUNITY TO SYNGENEIC METHYLCHOLANTHRENE INDUCED TUMOURS IN MICE. OCCURRENCE AND SPECIFICITY OF CONCOMITANT IMMUNITY
Author(s) -
Kearney R,
Nelson DS
Publication year - 1973
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1973.70
Subject(s) - methylcholanthrene , concomitant , immunity , neoplasm , ratón , cancer research , biology , immunology , pathology , medicine , immune system , carcinogen , genetics
Summary Mice bearing progressively growing Isografts of methylcholanthrene induced tumours resisted the growth of cells of the nine tumour Injected into the footpad. Resistance was manifested in two phases. In the first phase resistance was specific for the original tumour. In the second phase, the mice were resistant to other lines of syngeneic methyleholanthrene‐induced tumors. Mice from which the first tumour was completely excised during the development of the first phase had lost their resistance when challenged 5 days later. Mice From which the tumours had been Incompletely excised were as resistant as mice with intact tumours. It is concluded that the resistance of tumour‐bearing mice to footpad isografts of tumours is an example of concomitant immunity.