Premium
PATHOGENESIS OF THE GRAFT‐VERSUS‐HOST REACTION IN CHICKEN EMBRYOS. THE DEVELOPMENT OF HAEMORRHAGIC LESIONS
Author(s) -
Walker Karen Z,
Schoefl Gutta I,
Lafferty KJ,
Adams EP
Publication year - 1973
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1973.7
Subject(s) - spleen , embryo , pathogenesis , lymphatic system , inoculation , biology , pathology , platelet , electron microscope , andrology , anatomy , immunology , medicine , microbiology and biotechnology , physics , optics
Summary Adult, allogeneic lymphoid tissue was introduced into chicken embryos on day 4 or clay 6 by inoculation on the chorio‐allantoic membrane, intravenous injection or intracoelomic grafting. Severe haemorrhagic lesions appeared on the body surface and in the chorio‐allantoic membrane within 6 days after the inoculation of donor cells. However, there was no spleen enlargement in these embryos. The development of haemorrhages appeared to be the result of a graft‐versus‐host reaction since they were not observed in embryos inoculated with lymphoid tissue from a syngeneic adult donor. The vascular damage has been examined by light and electron microscopy. Vascular damage was associated with an elevation of lysosomal enzyme activity in the plasma ard the resulting haemorrhages could also be related to a low level of thrombocytes in the circulating blood.