Premium
FAILURE TO PRODUCE EXPERIMENTAL AUTOIMMUNE THYROTOXICOSIS IN RABBITS IMMUNIZED WITH THYROIDAL MICROSOMES
Author(s) -
Wall JR,
Good BF,
Hetzel BS
Publication year - 1973
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1973.66
Subject(s) - microsome , thyroid , endocrinology , medicine , iodine , immune system , thyroid function , immunization , chemistry , immunology , enzyme , biochemistry , organic chemistry
Summary Rabbits were immunized with human thyroidal microsomes, an equal number of control animals being immunized with the corresponding liver fraction. Assays for long‐acting thyroid stimulating‐like activity were carried out on the concentrated IgG fraction and thyroid function was assessed by plasma protein bound iodine and 131 I uptake measurements. The animals were examined for features of thyrotoxicosis. Despite intensive immunization designed to induce an experimental auto‐immune thyrotoxicosis, this could not be convincingly achieved, even though thyroid stimulating activity was detected in all animals that received thyroidal microsomes.