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THE EFFECT OF DIPYRIDAMOLE AND OF AMINOPHYLLINE ON RESPONSES TO SIXTY‐SECOND CORONARY ARTERY OCCLUSIONS IN DOGS
Author(s) -
Eikens E,
Wilcken DEL
Publication year - 1973
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1973.59
Subject(s) - aminophylline , dipyridamole , medicine , hyperaemia , coronary steal , cardiology , adenosine , reactive hyperemia , blood flow , anesthesia , coronary circulation , artery , heart rate , blood pressure , coronary vasodilator , vasodilation , myocardial infarction , coronary angiography
Summary Using electromagnetic flow transducers, we examined the effects of close arterial infusions of dipyridamole (1 μg/minute) and aminophylline (200 μg/minute) on reponses to adenosine, and on the reactive hyperaemic responses induced by 60‐second occlusions of the circumflex branch of the left coronary artery in anaesthetised dogs. Results were analysed only when pre‐occlusion coronary blood flow values and blood pressure and heart rate before, during and after coronary artery occlusion in pre‐ and post‐drug responses did not vary by more than 5%. Dipyridamole markedly increased the coronary blood flow response to adenosine (from + 32% ± 3·1 to ± 82% ± 7; means ± S.E.), while aminophylline reduced this response (from + 46% ± 6·2 to + 60% ± 2; means ±: S.E.). Despite this, reactive hyperaemia responses were not changed during either dipyridamole or aminophylline. These findings suggest that adenosine‐induced vasodilatation is not essential for the reactive hyperaemic resulting from 60‐second coronary artery occlusions.