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THE TRANSFER OF IMMUNOLOGICAL TOLERANCE WITH TOLERANT LYMPHOCYTES
Author(s) -
McCullagh Peter
Publication year - 1973
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1973.43
Subject(s) - parabiosis , spleen , immune tolerance , adoptive cell transfer , immunology , bone marrow , thoracic duct , biology , haematopoiesis , lymphocyte , microbiology and biotechnology , lymphatic system , stem cell , t cell , immune system
Summary Immunological tolerance of sheep erythrocytes has been transferred to normally reactive rats. Transfer could be effected by parabiosis of tolerant and normal rats or by the transfer of cell suspensions from a tolerant donor to a normal recipient. While thoracic duct lymphocytes and spleen cells from tolerant donors were highly effective in transferring tolerance, bone marrow cells were completely lacking in this capacity. Preliminary lymphocyte depletion of a prospective normal transferee assisted, but was not mandatory for, subsequent establishment of the tolerant state. It is suggested that tolerance of sheep erythrocytes is characterized by the presence of repressor cells.