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EFFECT OF ISOPRENALINE ON THE RESPONSE OF THE RABBIT EAR ARTERY TO ELECTRICAL STIMULATION
Author(s) -
Carroll PR,
Glover WE
Publication year - 1973
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1973.31
Subject(s) - phentolamine , stimulation , isoprenaline , tetrodotoxin , propranolol , medicine , contraction (grammar) , endocrinology , chemistry
Summary Isnprenaline greatly reduced the vasoconstrictor responses of the rabbit ear artery to short periods of electrical stimulation when parameters of stimulation were such that the response was also reduced by phentolamine and tetrodotoxin. This effect was abolished by propranolol and hence was due to stimulation of beta‐adrenoccptors. Responses to electrical stimulation in the presence of tetrodotoxin and phentolamine were resistant to the effect of isoprenaline. It is concluded that beta‐adrenoceptors exert their effect along an excitation‐contraction pathway used by nerve‐released transmitter but not by direct muscle stimulation.