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IMMUNE RESPONSES IN INTESTINAL TISSUES TO PARTICULATE ANTIGENS
Author(s) -
Robertson PW,
Cooper GN
Publication year - 1972
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1972.63
Subject(s) - lamina propria , immune system , antigen , spleen , mesenteric lymph nodes , microfold cell , lymphatic system , lymph , rosette (schizont appearance) , antibody , biology , immunology , submucosa , gut associated lymphoid tissue , intestinal epithelium , epithelium , pathology , medicine
Summary The kinetics of appearance of plaque‐forming and rosette‐forming cells in the spleen, blood and intestinal lymphoid tissues following single intravenous or intrajejunal injections of rats with sheep red cells have been compared. When antigen enters the body via the intestinal epithelium, local and general immune responses occur and both may contribute to antibody which appears in serum. The greatest response occurs in the mesenteric lymph nodes, and in these tissues it follows the pattern normally observed in lymphoid tissues following parenteral inoculation of antigen. Large numbers of rosette‐ forming cells appear rapidly amongst the cells of the intestinal lamina propria and submucosa; the plaque‐forming cell response is delayed by at least four days and is relatively small. It is suggested that the bulk of the latter cells are formed in other tissues and migrate to the lamina propria via the blood. The poor antibody‐forming capacity of the Peyer's patches has been demonstrated in these experiments, suggesting that these tissues may lie concerned with other immunological functions of the rat.