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THE NATURE OF THE RESPONSE OF THE CELLS OF THE SHEEP ERYTHROCYTE‐TOLERANT RAT TO TRANSFERRED ALLOGENEIC LYMPHOCYTES
Author(s) -
McCullagh Peter
Publication year - 1972
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1972.5
Subject(s) - clone (java method) , biology , population , immunology , lymphocyte , immune tolerance , microbiology and biotechnology , genetics , antigen , medicine , gene , environmental health
Summary The response of the cells of erythrocyte‐tolerant hosts into which allogeneic lymphocytes had been transferred to abrogate tolerance has been investigated. Following the abrogation of tolerance, rats were observed to respond poorly to re‐challenge with sheep erythrocytes, this behaviour probably being attributable to the re‐appearance of the tolerant state. The circulating lymphocyte was identified as the cell type in the tolerant host responsible for interaction with the transferred allogeneic cells. The re‐appearance of reactivity in a pre‐existing population of repressed, or tolerant, cells was considered to be a much more likely explanation for the phenomenon of allogeneic abrogation than the re‐emergence of a reactive clone of cells.