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IN VIVO OBSERVATIONS ON PLASMA CELLS IN THE RABBIT EAR CHAMBER
Author(s) -
Cliff WJ
Publication year - 1972
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1972.42
Subject(s) - stimulation , cytoplasm , antigen , in vivo , exudate , rabbit (cipher) , biology , immunology , pathology , in vitro , chemistry , microbiology and biotechnology , medicine , endocrinology , biochemistry , statistics , mathematics
Summary In vivo observations on plasma cells arising in rabbit ear chambers following stimulation with a variety of antigens are reported. The cells were non‐motile and had a yellow‐green coloration of their cytoplasm and showed highly characteristic peripheral cytoplasmic activity possibly related to clasmatocytosis. Plasma cells took three days to develop following initial antigenic stimulation and after a further three days showed a definite decline in their numbers. It is considered they probably arose from lymphoid cells present in the initial cellular exudate associated with antigen injection and they occurred in clusters closely associated with macrophages generally in the paravascular regions. Eosinophile leucocytes showed a predilection for these clusters. Repeated antigenic stimulation produced the Arthus reaction.