Premium
THE IN VITRO RESPONSE TO PHYTOHAEMAGGLUTININ (PHA) OF LEUCOCYTES FROM INTACT AND THYMECTOMIZED QUOKKAS
Author(s) -
Ashman R,
Keast D,
Stanley NF,
Waring H
Publication year - 1972
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1972.27
Subject(s) - phytohaemagglutinin , thymectomy , biology , immune system , in vitro , andrology , immunology , medicine , biochemistry , myasthenia gravis
Summary The in vitro leucocyte dose response curve to phytohaemagglutinin has been established for juvenile quokkas. Thymectomy of the neonatal quokka depresses this to less than half that of the normal animal. Surgical implantation of a superficial thymus from tammar ( Macropus eugenii ) pouch young does not reconstitute the humoral arm of the immune response of the Thymectomized quokka pouch young, nor does it lead to an acute graft‐versus‐host reaction. It does, however, cause a further depletion of phytohaemagglutinin‐sensitive cells in the peripheral circulation of these animals. Mixed leucocyte reactions with cells from thymectomized animals and thymectomized animals which had received tammar thymus grafts indicate that they are still able to recognize and reject xenogeneic tissue.