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DIFFERENTIAL EFFECT OF PIPERAZINE ON CHOLESTEROL METABOLISM IN MALE AND FEMALE RABBITS
Author(s) -
Redgrave TG,
West CE
Publication year - 1972
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1972.13
Subject(s) - piperazine , cholesterol , endocrinology , medicine , metabolism , aorta , biology , pharmacology
Summary Piperazine was added to the diet of cholesterol‐fed male and female rabbits. In male rabbits after a latent period of four weeks or longer hypercholesterolaemia was reduced. Cholesterol content of liver and aorta was also decreased. In contrast, hypercholesterolaemia of female rabbits was greatly increased by treatment with piperazine. The mechanism of this differential effect of piperazine on cholesterol metabolism in male and female rabbits is unknown, but it is suggested that our observation might prove useful in investigations of sexual differences in cholesterol metabolism.