Premium
EVIDENCE FOR INACTIVATION OF NORADRENALINE BY EXTRANEURONAL MONOAMINE OXIDASE IN THE RABBIT EAR ARTERY
Author(s) -
De La Lande IS,
Johnson SM
Publication year - 1972
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1972.10
Subject(s) - nialamide , monoamine oxidase , metaraminol , human ear , chemistry , medicine , monoamine oxidase inhibitor , amine oxidase , endocrinology , norepinephrine , basilar artery , monoamine neurotransmitter , biology , dopamine , serotonin , biochemistry , enzyme , blood pressure , physics , receptor , acoustics
Summary Untreated and nialamide treated rabbit ear arteries were incubated with noradrenaline in high concentration (20 μg/ml) and the subsequent rates of release of the amine into the bathing medium measured. Nialamide caused a 5–6 fold increase in the release. The effect was equally prominent in arteries treated with cocaine and in chronically denervated arteries. It is concluded that extraneuronal monoamine oxidase plays a major role in the inactivation of noradrenaline when the latter is present in high concentration in the tissue.