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SPONTANEOUS HYDRONEPHROSIS IN THE INBRED MOUSE STRAIN NZC
Author(s) -
Warner Noel L
Publication year - 1971
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1971.51
Subject(s) - hydronephrosis , backcrossing , inbred strain , biology , strain (injury) , genetics , physiology , medicine , endocrinology , gene , anatomy , urinary system
Summary An inbred strain of mice, NZC, was found to have a high incidence of spontaneous hydronephrosis, with up to 56% of males and 81% of females showing some stage of the disease. Either unilateral or bilateral hydronephrosis was found in mice between 80 and 660 days of age, and in most cases did not appear to have had a marked effete on survival time. Blood urea nitrogen levels in these mice were slightly elevated. NZC F 1 hybrid mice did not show the disease, nor did backcross progeny to normal parent strains. However, 43% of backcross progeny to the NZC parent showed hydronephrosis. These results indicate that a single autonomic recessive gene controls the inheritance of this renal disorder. The relation of this to other reported cases of hydronephrosis and to other genetic disorders in NZ mice is discussed.