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THE RELATIVE ANTIBACTERIAL EFFICIENCY OF IgM, IgG AND IgA FROM PIG COLOSTRUM
Author(s) -
Knop J,
Breu H,
Wernet P,
Rowley D
Publication year - 1971
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1971.42
Subject(s) - opsonin , phagocytosis , colostrum , antibody , microbiology and biotechnology , immunology , immunoglobulin a , immunoglobulin m , immunoglobulin g , humoral immunity , immune system , immunity , intracellular , biology , antibody opsonization , chemistry , biochemistry
Summary IgA, IgG and IgM have been isolated and purified from colostrum of two sows immunized with E. coli 0111. The three immunoglobulin classes have been tested for their direct bactericidal action with complement and for their opsonic and intracellular killing activity in a test using mouse peritoneal phagocytes. IgA showed only marginal bactericidal action with complement in contrast to IgM and IgG. However, the specific IgA antibody was found to be more active in promoting phagocytosis and intracellular killing than either IgM or IgG. These observations suggest that IgA may play an important role in intestinal immunity.