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GANGLIONIC BLOCKADE BY RHAZIDINE
Author(s) -
Bhattacharya BB,
Chaudhuri SK,
Ganguly DK
Publication year - 1971
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1971.41
Subject(s) - nictitating membrane , hypogastric nerve , stimulation , vas deferens , blockade , ganglion , ganglionic blocker , nicotine , guinea pig , sympathetic ganglion , endocrinology , medicine , chemistry , pharmacology , hexamethonium , receptor , anatomy , statistics , classical conditioning , mathematics , conditioning
Summary Rhazidine, a monoquaternary alkaloid, exhibited considerable ganglion blocking property. Responses of the nictitating membrane to pre‐ganglionic sympathetic stimulation were abolished without affecting post‐ganglionic responses. Responses of the vas deferens to hypogastric nerve stimulation were impaired without altering the responses to intramural stimulation in the guinea‐pig. Only partial inhibition of response was observed in the guinea‐pig urinary bladder to hypogastric nerve stimulation. Spasms induced by nicotine were selectively inhibited in all of the test organs. Effects at adrenergic neuron and post‐synaptic receptors were excluded. The results were compared with pentolinium lartarate and indicated specific ganglion blocking effect of rhazidine.